Study in mice suggests that component keeps stem cells from generating new tumors.
THURSDAY, May 6 (HealthDay News) — Eating broccoli just might have benefits in the fight against breast cancer.

At least in mice, a compound derived from broccoli appears to be able to kill breast cancer stem cells, which help tumors grow, according to a new study. But it’s too soon to know if the compound would work in people. And the amount tested is larger than the amount people could consume in their diet.

The compound, known as sulforaphane, “has been studied previously for its effects on cancer, but this study shows that its benefit is in inhibiting the breast cancer stem cells,” study co-author Duxin Sun, an associate professor of pharmaceutical sciences at the University of Michigan College of Pharmacy, said in a university news release.

The researchers administered sulforaphane to mice with breast cancer and monitored the number of cancer stem cells in their tumors. They found that the treated mice had fewer of the cells and that they couldn’t generate new tumors. Tests on human breast cancer cells in the laboratory resulted in similar decreases in cancer stem cells, they reported.

“This research suggests a potential new treatment that could be combined with other compounds to target breast cancer stem cells,” Dr. Max S. Wicha, an oncology professor and director of the university’s Comprehensive Cancer Center, and also a study co-author, said in the news release. “Developing treatments that effectively target the cancer stem cell population is essential for improving outcomes.”

The study was published May 1 in Clinical Cancer Research.

More information

Visit the American Cancer Society for more about breast cancer.

– Randy Dotinga

SOURCE: University of Michigan, press release, May 3, 2010

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One in eight women in the United States will develop breast cancer. Most women know of someone who has been affected by this disease and wonder what can they do to protect themselves from breast cancer. A new analysis study found 40% of all cases of breast cancer could be prevented with lifestyle changes.

The study, from the research groups American Institute for Cancer Research and the World Cancer Research Fund, is the largest review of research examining lifestyle and breast cancer; the groups analyzed nearly 1,000 studies. The study found that lifestyle changes concerning certain risk factors may help prevent breast cancer. The best advice today to help lower the risk of breast cancer is to maintain a healthy body weight, especially after menopause.

Other recommendations from the study include: eat healthy foods, limit or avoid alcohol, exercise and breastfeed your baby.

Healthy Foods: Eat more foods which may be linked to helping prevent breast cancer, including more fruits, vegetables, beans and whole grains. Fill two-thirds of your plate with plant-based foods – fruits, vegetables, whole grains and beans. Include whole grains, canned tomato products such as pasta sauce, and cruciferous vegetables (including cabbage, broccoli and cauliflower) often as these foods may offer a protective effect against breast cancer.

Move More: Women should get 30 minutes of exercise or physical activity each day. According to the National Cancer Institute, women can reduce their risk of dying from breast cancer by 25% with exercise.

Limit Alcohol: Women should limit their alcohol consumption to no more than one drink each day or avoid it all together.

Breastfeed Baby: There is convincing evidence that breastfeeding lowers breast cancer risk.

Remember – monthly breast exams and annual mammograms are important for early diagnosis and treatment of breast cancer.

Here are some great tips from: http://www.hy-vee.com/health/healthy-bites/think-pink-tips.aspx

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